![]() ![]() However, when applied alone the antagonist raised the peristaltic threshold suggesting that it prevented the action of locally released 5-HT. Applied to the lumen they blocked the effect of co-administered 5-HT. LSD and 2-bromo- d-LSD were used as 5-HT antagonists. Removing the mucosa from the loop of intestine or luminal application of cocaine or procaine abolished the peristaltic reflex and under these conditions luminal 5-HT had no effect. Application of 5-HT to the bath invariably caused inhibition of peristalsis, even when this was already stimulated by intraluminal 5-HT. Adding 5-HT to the lumen dose-dependently decreased threshold with a threshold concentration around 1 n m. In the guinea-pig ileum peristalsis was triggered initially by a pressure rise of just 1–1.5 cmH 2O, rising to about 2 cmH 2O after an hour or so. Their major findings can be summarized as follows. ![]() Yet, with cleverly designed protocols and enormous insight Bülbring and Lin established a concept for control that still holds 50 years later. The paper is also very descriptive so that the reader can get a real feel for the whole study design, problems that were encountered and overcome, variability in responses and there's not a P value in sight. Assay for endogenous 5-HT was based on strips of rat stomach, uterus and colon rather than HPLC or amperometry. Limited pharmacological tools reflect the lack of appreciation at the time of the range of 5-HT receptor subtypes that are now known to be expressed in the gut mucosa and which influence sensory signalling. Reading again about kymographs and ‘home-made’ piston and float recorders to monitor pressure and volume contrasts with modern descriptions of solid-state electronics, digital devices and computer analysis. This classic paper describes the methodological developments that were necessary to record the propulsion of luminal contents by pressure-evoked peristalis in the guinea-pig ileum (and rabbit jejunum) during application of 5-HT to the lumen, and gives a detailed account of experiments designed to unravel the role of 5-HT in sensory signalling.įirst, a word or two about the available methodology. Bülbring and Lin therefore set out to ask the beautifully simple question – what happens if 5-HT is applied not to the serosa but to the mucosa? Their hypothesis was that this would mimic release of endogenous 5-HT which in turn would activate receptors associated with mucosal sensory mechanisms. In contrast, when 5-HT was applied to isolated intestinal segments in an organ bath it inhibited or abolished the peristaltic reflex ( Kosterlitz & Robinson, 1957). Carcinoid syndrome, in which there is massive outpouring of 5-HT from mucosal enterochromaffin cells, is characterized by increased intestinal activity and diarrhoea. However, there was also something of a dilemma. It was also evident that there was a rich source of 5-HT in the gastrointestinal tract and that this was mainly within the mucosal epithelium ( Feldberg & Toh, 1953). ![]() They had also demonstrated that the peristaltic reflex could be triggered by distension, but required a sensory mechanism within the mucosa since it was lost after removal of the mucous membrane or following topical application of local anaesthetic. It serves as a who's who in serotonin research and catalogues the development of our understanding of the role that 5-HT plays in sensory signalling from the gut lumen.īülbring had already shown in early publications that the peristaltic reflex was entirely mediated by neural mechanisms within the bowel wall since degenerative section of the extrinsic innervation had no effect on reflex activity ( Bülbring et al. It is interesting to look through the citation records of classic papers such as this – Bülbring & Lin (1958). ![]()
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![]() ![]() ![]() Choose any of the user-favorite DNS providers or configure a custom DNS server. ![]() Blocking regular online trackers is not enough if you want to assure 100% protection of your online privacy. Add your own filters by URL even if they are not on the default list. Together they don't leave ads a chance.ĪdGuard Premium includes the following features: More than 50 popular subscriptions (EasyList, EasyPrivacy, etc.) plus AdGuard's own powerful ad filters, including language-specific filters. By blocking them, you’re saving your battery life and Wi-Fi/mobile traffic. Banners and ads sometimes add up to half the size of the page. Reduced traffic consumption and increased battery life. AdGuard removes tons of rubbish and you can freely surf the web! AdGuard offers a selection of filters aimed directly at trackers and web analytics that will ensure your private data stays that way. The web is full of trackers that literally watch your every click. Whitelist your favorite websites or use manual blocking tool to hide any element on the page. Say goodbye to annoying banners, pop-ups and video ads. The app is free but offers additional paid Premium features for advanced users. AdGuard for iOS is an open source app, it’s totally transparent and safe to use. It will not only remove annoying ads but also secure your privacy with advanced tracking protection. AdGuard is an ultra-efficient ad blocker for Safari. ![]() ![]() ![]() I will test the Mac Studio as far as I can in the coming weeks, but based on what I have seen so far, I fully expect both the M2 Max and the M2 Ultra to perform as you would expect - and most likely exceed expectations. There was another instance where 700 channels of instruments were running alongside each other, allowing for individual controls of each channel, while an 8K video was also running in the background and there wasn't even a murmur of struggle, so the raw power offered here is excellent. A 3D image was created in Maya - now native to Apple Silicon - in a few minutes, while the Mac Studio with an M2 Ultra chip simultaneously ran 12 videos, all 4K Pro-Res, allowing for a very quick and simple multi-angle edit. Apple says the media engines collaborate better together and that was clear in the demos. I also saw a Mac Studio with M2 Ultra chip handle 3D images without breaking any kind of sweat at all, as well as multiple 4K Pro-Res videos. ![]() It took around 10 seconds for the Mac Studio I saw to auto-blend the layers in Photoshop and create an image that combined the best elements of all six images into one image that was sharp and had everything in focus. One model with the M2 Max chip like my review model handled six images at 150-megapixels each with ease. During my time at WWDC, I saw the Mac Studio running the kind of programmes it would be expected to. I don't have the top-spec model, but even the middle of the line Mac Studio that I have in for review is more power than most would need. I am still testing the performance of the Mac Studio, though from my time so far, there's an exceptional experience here. The top-end model of the Mac Studio with the M2 Ultra will set you back $8799 in the US or £8999 in the UK so it's not a small purchase by any stretch of the imagination. More than many of us would know what to do with half of, let alone the full whack. There are also unified memory options of 64GB, 128GB and 192GB, while storage options range from 1TB to 8TB so we're talking about some serious power here. By comparison, the M1 Ultra chip had a 20-core CPU and up to 64-core GPU. The M2 Ultra meanwhile, is an entirely new chipset, with the base model offering a 24-core CPU with 16 high-performance cores and 8 efficiency cores, alongside a 60-core GPU, though it is configurable up to 76 graphics cores. The design works, with an SDXC card slot and two Thunderbolt 4 or USB-C ports (model dependant) conveniently positioned on the front, alongside the status light to the right, while the rear houses the rest of the ports, of which there are several. ![]() Nothing has changed in terms of design compared to the Mac Studio (2022), but that's definitely not a criticism. ![]() There are rounded edges, flat sides, a flat top with a polished Apple logo and a tapered bottom with grille holes for the fan and it's every bit as premium as you would expect. There's no reaching around a big monitor here. The Mac Studio is around twice the height of the Mac mini and it sits on top of your desk, resulting in a neat and tidy offering, but more than that, easy access to all the ports. In our setup, we have the Studio Display, Magic Keyboard and Magic Trackpad, and they are a delight to use together. That means that like the Mac mini, you buy a display, keyboard, trackpad or mouse all individually, unless of course you have them already. ![]() ![]() We round down to a max string size of 17 panels. Max string size: 25 optimizers or 6,000 watts (whichever is smaller)ĭivide the panel wattage by the maximum string input to ballpark your maximum string size:.Minimum string length: (8) P370 or P400 optimizers.Go back to the optimizer spec sheet and scroll down to the bottom where it covers system design: SolarEdge system design specsīased on our single-phase HD-wave 7600 inverter and P400 optimizer, we can now determine minimum and maximum string size: Next, we need to figure out our string size-the number of panels that can be wired into a single input on the inverter. With those values covered, we know we can safely pair either the P370 or P400 with Astronergy’s 345W panels. The P370 satisfies these benchmarks as well. The P400’s 80V max input voltage covers the 46.37V open-circuit voltage of the panel, and its 10.1A short circuit current is enough to handle the 9.67A current from the panel. The P370 and P400 both have a high enough DC input rating to cover the 345W output of the solar panel. Let’s start by looking at the spec sheet for the standard optimizers: Input ratings for SolarEdge power optimizersĬompare the optimizer input requirements to the solar panel’s spec sheet to make sure the voltage and current are within spec: Astronergy solar panel specs These optimizer models work with SolarEdge inverters: Picking the right optimizer is fairly easy when you look at the input section on the optimizer spec sheet. ![]() ![]() Step 2: Pick an optimizer for your inverter Now that we know which inverter we’ll be using, we can pair the appropriate optimizer. In this case, I would suggest the SE7600H unless you plan to expand your system down the road. Oversizing your PV array will better utilize that inverter, resulting in lower system costs with similar production. The array is usually not producing at max power due to real-world losses caused by cloud cover, high temperatures, and module soiling. It’s fairly common for your solar array DC wattage to be greater than the inverter output. The SolarEdge SE7600 outputs 7,600 watts, but can safely handle 11,800 watts of input from the array. Note that inverters have different input and output ratings. On the other hand, the SE10000H would allow some room for future expansion. The SE7600 would be easier to install, because it can go on a standard 200 amp service panel without derating the main breaker or doing a line side connection. In this case, the SE7600H and SE10000H inverters both appear to be a good fit as they can both handle the input from our 10.35kW array. Max DC Power ratings for SolarEdge inverters We choose 240V because that is the standard voltage on most electrical service panels installed on residential properties. To determine which inverters are suitable, check the inverter spec sheet for the maximum DC power 240V for each model. Once we know our desired array size, we need to pick an inverter that is large enough to handle the input from the array. The array size is 10,350 watts or 10.35 kW: In our example, we’re going to design for an array with 30 Astronergy 345W solar panels. Step 1: Match DC Array Size to Inverter Input Size
![]() ![]() It comes with two Gigabit Ethernet ports and you will enjoy a speedy internet connection. This cable modem offers download speeds up to 343 Mbps and Wi-Fi speeds up to 1600 Mbps. If you like to ditch the rental, then this is the best option for you. It is compatible with every internet and cable supplier except AT&T, CenturyLink, etc. If you want a device that has an easy setup, then this is the best option for you. As it comes with a sleek design, you can place it anywhere in your home. You can connect this with any Wi-Fi router and it offers one Gigabit Ethernet port. It supports an internet plan with speeds up to 300 Mbps and also supplies reliable connections. If you are using Xfinity or Optimum as your Internet Connectivity, then Netgear CM500 is ideal for you. In this modem/router combo, you will get two Gigabit Ethernet ports and also one USB port.īest for Xfinity or Optimum: Netgear CM500 You can use it anywhere and it is perfect for an apartment, office or even a large residence. If you connect multiple devices, then also you will get a strong connection. If you want the internet connection to not stop you from the streaming of Netflix or Hulu, then it is the perfect cable modem/router combo for you. If you are using multiple devices, then also you will get high connectivity. If you are using a wired connection, then the speed you get that will surprise you. Wireless connection is the weak point of this modem. It is a dual-band device that comes with two Gigabit Ethernet ports and dual antennas. If you have a small home or office, then it will be perfect for you. Netgear C3700 supplies all the connectivity and you will be free from paying a monthly fee to your ISP. You can easily connect Motorola MG7550 with all your devices. But this helps you to save a monthly rental fee. So, if your bundle includes a voice, then it will be problematic for you. Here you will not find any type of telephone jack and because of that, you will not be able to connect any phone. ![]() It has a wireless power boost that helps you with fast connectivity for all your wired or wireless devices. Generally, it is compatible with most cable providers except for fiber optic, DSL, etc. If you are working with the Gigabit Internet, then Motorola MG7550 is perfect for you. Though a bit expensive, with all its excellent features and functionalities, it’s surely worth a shot.īest for Gigabit Internet: Motorola MG7550 And, with AC3000 speed, Tri-Band wireless connections, and many ethernet ports, you’ll have no problem connecting all your devices to it. It provides a reliable internet connection and excellent MU-MIMO support. This combo covers large areas, up to 5000 sq.ft and while you may not need the whole coverage, it still is a better alternative when you want to cover your home or office space with a single modem/router combo. Netgear Orbi is one of the most reliable routers available in the market, and that’s not for nothing. If anyone wants to upgrade their modem or router setup then undoubtedly this is the best choice. And the list provided by us will surely help you decide. ![]() It’s a great choice to use a modem/router combo for reducing clutter and while many ISPs will offer you the same for a monthly rental, you’ll do good in the long run if you buy one today. Best for Xfinity or Optimum: Netgear CM500.Best for Gigabit Internet: Motorola MG7550. ![]() ![]() ![]() ![]() PO Box Oaks PA I dont know who it is so I googled Im happy I did my husband and I. If you choose to do business with this business, please let the business know that you contacted BBB for a BBB Business Profile.Īs a matter of policy, BBB does not endorse any product, service or business. This may be a scam because the phone numbers do not match. Box 1259Oaks, PA 19456May 17, 200KASSOCIATED RECOVERY SYSTEMSA DIVISION OF ARS NATIONAL SERVICES. BBB Business Profiles are subject to change at any time. If I settle what should I take notice ofDepartment /I 5996P.O. When considering complaint information, please take into account the company's size and volume of transactions, and understand that the nature of complaints and a firm's responses to them are often more important than the number of complaints.īBB Business Profiles generally cover a three-year reporting period. However, BBB does not verify the accuracy of information provided by third parties, and does not guarantee the accuracy of any information in Business Profiles. Commonwealth Health Physician Network walk-in clinics are here to provide urgent and primary care services to you and your family six days a week, with no appointment needed. ![]() BBB asks third parties who publish complaints, reviews and/or responses on this website to affirm that the information provided is accurate. About Us Directions Walk-In Clinics Walk-In Clinics. BBB Business Profiles may not be reproduced for sales or promotional purposes.īBB Business Profiles are provided solely to assist you in exercising your own best judgment. ![]() ![]() Ham's name is an acronym for the lab that prepared him for his historic mission the Holloman Aerospace Medical Center, located at Holloman Air Force Base in New Mexico. He was not originally wearing such a space suit, but was made to wear a pressurized suit (also called a space suit), which was worn by humans in Project Mercury. Born in present-day Cameroon, captured by animal trappers and sent to Miami, FL. The space suit is made of translucent, hard-to-see material. The reason why the head of this work is translucent (paraffin wax) is because Ham is still an animal that has left its mark on history in space development, but I dared to use a translucent material that is difficult to see, with the meaning of "invisible existence" that we humans were able to safely go into space at the expense of many nameless animals. ![]() Hamm returned safely to Earth and survived for the next 17 years. Mercury mission to send humans into space (strictly speaking, ballistic). The motif of this work is "Ham," a chimpanzee who made a ballistic flight ahead of the astronauts on January 30, 1961, to confirm the safety of the U.S. In order to obtain this information, various insects, reptiles, mammals, and fish, from small fruit flies to chimpanzees, were sent into space, and some of them lost their lives. Victims of attacks by the V2 rocket developed as a weapon during World War II, forced labor in factories, and so on.Īfter the war, a full-scale space race began, and there was a lack of information to send humans to the moon. The history of space exploration exists on the basis of many sacrifices. They included hitting simple levers to get a treat they concluded that Ham was pretty smart. ![]() It explains that when he was two years old, he was purchased by the US Air Force and was trained to complete simple tasks. Materials: NASA documents, cardboard, Japanese paper, paraffin wax, plastic board The video starts with incredibly cute footage of Ham as a baby chimp. ![]() ![]() ![]() The AverMedia Live Gamer Portable 2 Plus excels above some of its competition in the mid-range market because of its versatility. You can expect to pay around $159.99 / £141.99 / $AU221.45, though you can frequently find it cheaper than this as discounts are common. Still, for the price tag, it’s hard to argue against if you’re after something multi-purpose for console streaming.ĭespite being nearly five years old, the AverMedia Live Gamer Portable 2 Plus continues to thrive as one of the best capture cards in terms of its price to performance. Now, we should stress that you won’t get the same level of consistent quality as you would from a larger box with better encoding. For the relatively low asking price of $49.99 / £54.44 / AU$89.99, that’s some serious bang for your buck all wrapped up in a form factor that no other capture card can quite compare to right now. You can mirror the gameplay from a smaller screen to a larger one, and record through the Genki Arcade program on your computer. It plugs into any compatible games console, such as the PS5, Xbox Series X, Nintendo Switch, or Steam Deck via HDMI input and then outputs via USB-C to USB-A in 1080p60 to devices such as a gaming TV or gaming monitor. The Genki ShadowCast is a full-featured screen capture and mirroring device that’s the size of a typical USB thumb drive. Have you ever wanted a pocket-sized capture card? If so, you can search no longer. While an investment, there’s no denying the quality and versatility here. Should you want to plug into a PC, the capture card features USB 3.0 connectivity and full support for the likes of OBS Studio and direct access to Twitch and YouTube. What’s particularly impressive about the 4K60 S+ is the HEVC chip which allows for lossless encoding for reliable picture quality with little to no artifacts over the native picture. We can only recommend this to seasoned streamers looking for an upgrade or those with serious cash to burn. ![]() With its asking price of $399.99 / £389.99 / AU $628, this isn’t going to be the capture card that you start with. These innovations don’t come cheap, though ultimately, that’s what stops the Elgato 4K60 S+ from taking the top spot. However, its biggest selling point is that you can record entirely without a computer, as it can record footage to an SD card. In terms of raw features and resolution support, the Elgato 4K60 S+ can certainly be considered the best capture card for 4K. ![]() ![]() ![]() I really don't want to step on anyone's toes again. The one guy yeah, comes out and just goes like, is it? Is it my turn? So at any rate, you know, I do sort of managed to pull out of the skin and I just and I just kind of pretend that I fell asleep.Īnd and the Groundlings make a lot of hay out of that. You know, I've been putting my place, you know, and I feel bad. But at any rate, they did not want me to play feel it still by Portugal, the pan.Īlthough it is sort of holiday themed, isn't it? And it is your turn, Adam. You think they were playing the same song? I think Vlad was doing good king Wenceslas. We didn't have like a seasonal theme or anything like butĭate but you know, they're playing. ![]() Where we also didn't have Mad, Mad respect. Yeah, it's not unlike this is the Christmas show of our episode or the holiday show. We were supposed to be playing first Noel. And I goĪnd of course it's the Christmas show. I want it to go and put and the drums are going. But even though you must be thinking like, well, this is gonna make the audience. But so you feel a pressure to like contribute. Know that you can't ruin the show? You can't make it bad? Well, these guys are fucking pros. And and I hope that it comes out and and is it comforting to And I finally reach out to the keys and I just go like, you know, Satan take the wheel. But with the pressure of these, you know, the Sunday company is about to step out and actually like start do some of these unusual conversations that they perform, where two people are both being weird characters, right and there and like an airport bar Yeah,Īnd I'm and I know the songs like the back of my hand. And I'm actually like, here in person like about to do it and because I had my way, you're gonna be ready blank. lights come up a blind starts banging the drums and I am finally hit with the weight of what we're doing that I am now in the little band that plays next to the ground link stage. And I'm like, there's going to be great, there's going to be great. I have a tiger and dad.īen is also just in the zone. And I turned a blind dinner and she's ready. They're telling you one out nice The show is Josh. Stitcher premium gifting is available in three months weighing our options. What's the matter? She thinks it shows to mean we've gotten that before. Gave the podcast lover in your life the gift of 21,000 hours of premium content content, ad free listening exclusives, bonus episodes stand up comedy I was so much more who does stand up on there. I also was raised by the show house where we all raised by house recent episode of respect TV you remember when we were growing up watching house seven years ago Happy Hanukkah, Josh, I was raised by TV. ![]() My mom she was most excited about getting Or the same number they don't want to advertise it. Is it on premium only? You know, I think it's not I think it's available widely right? But it's a stitcher production. And I don't read ads for that for some reason, but I gotta read ads for all this other crazy shit. There's this showĬalled the dream that I actually think is really good. ![]() Here's a code for stitcher premium so you can listen to the behind the paywall podcasts that I make I wanted to try to do something that would mean a lot to you. Your friends and family stitcher premium dear friends and family. Searching for the perfect holiday gift Look no further situations premium gifting is now available. Stitcher premium gifting host read copy still Laser that's gonna blast me for not obeying the Stitcher ![]() ![]() Once the layers have set, use a marijuana leaf shaped cookie cutter to cut jello shots. Pour in the green mix over the hardened white mix and refrigerate once more.ħ. Stir well and add to the mix once it is cool.Ħ. Step 2 Add THC gummies to boiling water and stir until dissolved. In a separate bowl, combine spiced rum, melon liqueur, and blue curaçao. Step 1 If using oranges, slice them in half and scoop out the flesh. In another pot, boil pineapple juice and 2 packets of unflavored gelatin. Use nonstick spray on a pan or baking sheet and pour in the mix. Add sweetened condensed milk and stir well. In a pot, boil together water and 2 packets of gelatin. But if you like these Marijuana Leaf Shaped Jello Shots and prefer to keep your toking a little more low key, you'll also probably like these: the Long Island Iced Tea, the Jäger Bomb, Oil Spill Shots, and the Sour Green Apple.ġ. For some other drinks that fit the 420 theme but don't have any THC them, check out our Liquid Marijuana Cocktail, Marijuana Jungle Juice bowl, Marijuana Milkshake Shot, and our Bong Water drink. Instructions How to make it: Add jello to boiling water and stir until combined. And best of all, it takes just a few minutes to make THE BEST LIQUID MARIJUANA SHOT. Plus, you probably already have all the ingredients in your home bar, especially if you’re a cocktail fan. While these Marijuana Leaf Shaped Jello Shots don't contain any real marijuana or tincture of cannabis, it's still a fantastic drink that goes well with the 420 theme. This liquid marijuana shot is the perfect recipe if you’re into sweet and fruity drinks. Spiced rum, melon liqueur, coconut rum, and blue curacao are mixed with pineapple Jello to make a sweet and wonderful liquid marijuana jello shot. This tasty green cocktail recipe mixes up jello, coconut rum, pineapple juice, spiced rum, midori melon liqueur, and blue curacao, and is obviously perfect as a 420 drink recipe. Ladies and gentlemen, here we present to you the Marijuana Leaf Shaped Jello Shots. ![]() |
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